General Information of Drug (ID: DMT27QD)

Drug Name
CHYMOSTATIN Drug Info
Synonyms
Chymostatin; CHEMBL247767; AC1L9E22; MRXDGVXSWIXTQL-HYHFHBMOSA-N; C11308; 9076-44-2; SCHEMBL8259564; BDBM87059; CHEBI:510447; C31H41N7O6; BDBM222139; LS-187745; X6871; FT-0623815; (2S)-2-[[(1S)-2-[[(1S)-1-[[(1S)-1-benzyl-2-oxo-ethyl]carbamoyl]-3-methyl-butyl]amino]-1-(2-iminohexahydropyrimidin-4-yl)-2-oxo-ethyl]carbamoylamino]-3-phenyl-propanoic acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
443119
ChEBI ID
CHEBI:510447
CAS Number
CAS 9076-44-2
TTD Drug ID
DMT27QD

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Chymase (CYM) TT8VUE0 CMA1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Chymase (CYM) DTT CMA1 2.848 4.517 4.615 3.406
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Chymase (CYM) DTT CMA1 3.36E-05 -0.62 -3.21
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Identification of 6-substituted 4-arylsulfonyl-1,4-diazepane-2,5-diones as a novel scaffold for human chymase inhibitors. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3431-4.