Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMT4QRD)

Drug Name
RG-4929 Drug Info
Synonyms R-4929; RO-5093151; 11-beta HSD inhibitor (type 2 diabetes), Roche; 11-beta hydroxysteroid dehydrogenase inhibitor (type 2 diabetes), Roche
Indication
Disease Entry ICD 11 Status REF
Metabolic disorder 5C50-5D2Z Phase 2 [1]
Cross-matching ID
PubChem CID
21846
CAS Number
CAS 5633-14-7
TTD Drug ID
DMT4QRD

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) TTN7BL9 DHI1_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DTT HSD11B1 10.967 5.178 5.865 6.377
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Metabolic disorder
ICD Disease Classification 5C50-5D2Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) DTT HSD11B1 2.03E-01 -0.01 -0.08
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT01493271) A Study of RO5093151 in Patients With Ocular Hypertension Or Open Angle Glaucoma. U.S. National Institutes of Health.
2 New Therapeutic Strategies for Type 2 Diabetes: Small Molecule Approaches. 2012. Chapter 5. Page(131).