Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMTDWIE)

Drug Name
BRX-005 Drug Info
Synonyms Arimoclomol maleate; BRX-220; Bimoclomol derivatives, Biorex
Indication
Disease Entry ICD 11 Status REF
Diabetic foot ulcer BD54 Phase 1 [1]
Amyotrophic lateral sclerosis 8B60.0 Discontinued in Phase 2 [2]
Cross-matching ID
PubChem CID
6421776
CAS Number
CAS 276690-58-5
TTD Drug ID
DMTDWIE

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Heat shock protein 70 (HSP70) TTHYBIX HS71A_HUMAN; HS71B_HUMAN Modulator [3]

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Diabetic foot ulcer
ICD Disease Classification BD54
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Heat shock protein 70 (HSP70) DTT HSPA1A; HSPA1B 1.03E-20 0.32 1.2
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013054)
2 Bimoclomol: a nontoxic, hydroxylamine derivative with stress protein-inducing activity and cytoprotective effects. Nat Med. 1997 Oct;3(10):1150-4.
3 Cardiovascular effects of BRX-005 comparison to bimoclomol. Life Sci. 2000 Aug 25;67(14):1783-9.