General Information of Drug (ID: DMTE3UV)

Drug Name
BI 1467335 Drug Info
Synonyms
PXS-4728A; 1478364-68-9; BI-1467335 HCl; UNII-6W2049SJPH; 6W2049SJPH; PXS 4728A; 1478364-68-9 (HCl); (E)-4-((2-(Aminomethyl)-3-fluoroallyl)oxy)-N-(tert-butyl)benzamide hydrochloride; PXS 4728 HCl; BI-1467335 hydrochloride; CHEMBL3897599; SCHEMBL16766775; EX-A4639; AC-31510; Benzamide, 4-(((2E)-2-(aminomethyl)-3-fluoro-2-propen-1-yl)oxy)-N-(1,1-dimethylethyl)-, hydrochloride (1:1); HY-112726; CS-0062985; Q27265609; (E)-4-(2-(aminomethyl)-3-fluoroallyloxy)-N-tert-butylbenzamide hydrochloride
Indication
Disease Entry ICD 11 Status REF
Diabetic retinopathy 9B71.0 Discontinued in Phase 2 [1]
Cross-matching ID
PubChem CID
71812246
CAS Number
CAS 1478364-68-9
TTD Drug ID
DMTE3UV

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Membrane copper amine oxidase (AOC3) TT7HC21 AOC3_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Membrane copper amine oxidase (AOC3) DTT AOC3 7.055 8.263 6.709 7.374
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Diabetic retinopathy
ICD Disease Classification 9B71.0
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Membrane copper amine oxidase (AOC3) DTT AOC3 8.36E-22 -1.03 -1.54
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Clinical pipeline report, company report or official report of Boehringer Ingelheim.