Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMTIESG)

Drug Name
Omburtamab Drug Info
Indication
Disease Entry ICD 11 Status REF
Neuroblastoma 2D11.2 Phase 2/3 [1]
Cross-matching ID
TTD Drug ID
DMTIESG

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
B7 homolog 3 (CD276) TT6CQUM CD276_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Neuroblastoma
ICD Disease Classification 2D11.2
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
B7 homolog 3 (CD276) DTT CD276 3.92E-01 -0.04 -0.81
B7 homolog 3 (CD276) DTT CD276 7.33E-02 -0.53 -1.33
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT03275402) 131I-omburtamab Radioimmunotherapy for Neuroblastoma Central Nervous System/Leptomeningeal Metastases. U.S. National Institutes of Health.
2 Mast cell proliferation in the cerebrospinal fluid after intraventricular administration of anti-B7H3 immunotherapy. Cancer Immunol Immunother. 2021 Feb 3.