Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMTLP1N)

Drug Name
Combinectin Drug Info
Synonyms GSK3732394
Indication
Disease Entry ICD 11 Status REF
Human immunodeficiency virus infection 1C62 Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMTLP1N

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Human immunodeficiency virus Glycoprotein 41 (HIV gp41) TTG90S6 ENV_HV1H2 Inhibitor [2]
T-cell surface glycoprotein CD4 (CD4) TTN2JFW CD4_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
T-cell surface glycoprotein CD4 (CD4) DTT CD4 6.916 5.411 5.066 5.635
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Human immunodeficiency virus infection
ICD Disease Classification 1C62
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
T-cell surface glycoprotein CD4 (CD4) DTT CD4 9.36E-04 0.67 2.62
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT03984812) Evaluation of the Safety, Tolerability and Pharmacokinetics (PK) of GSK3732394 First-Time-in-Human (FTIH) Study. U.S. National Institutes of Health.
2 Clinical pipeline report, company report or official report of ViiV Healthcare.