Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMTM1LK)

Drug Name
YM-355179 Drug Info
Synonyms YM-355179; GTPL793; SCHEMBL3808393
Indication
Disease Entry ICD 11 Status REF
Asthma CA23 Preclinical [1]
Cross-matching ID
PubChem CID
11556309
TTD Drug ID
DMTM1LK

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
C-C chemokine receptor type 3 (CCR3) TTD3XFU CCR3_HUMAN Antagonist [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
C-C chemokine receptor type 3 (CCR3) DTT CCR3 3.982 4.271 3.838 3.609
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 12 Disease of the respiratory system
Disease Class ICD-11: CA23 Asthma
The Studied Tissue Nasal and bronchial airway
The Studied Disease Asthma [ICD-11:CA23]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
C-C chemokine receptor type 3 (CCR3) DTT CCR3 2.97E-06 -0.44 -0.48
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 793).
2 Emerging drugs for asthma. Expert Opin Emerg Drugs. 2008 Dec;13(4):643-53.