Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMTPRXI)

Drug Name
NSC-316158 Drug Info
Synonyms NSC316158; NSC-316158; 1,4-dihydroxy-2-[3-(2-hydroxyethylamino)propylamino]anthracene-9,10-dione; AC1L8UB6; CHEMBL1161925; ZINC5390383; NCI60_002718
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
432861
TTD Drug ID
DMTPRXI

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Quinone reductase 1 (NQO1) TT8XK6L NQO1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Quinone reductase 1 (NQO1) DTT NQO1 5.453 7.493 8.082 7.086
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Quinone reductase 1 (NQO1) DTT NQO1 2.05E-04 0.89 2.67
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 In silico identification and biochemical characterization of novel inhibitors of NQO1. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6246-54.