Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMTQIB2)

• Drug Name: Anti-MUC1 CAR-T cells Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Colorectal cancer	2B91.Z	Phase 1/2	[1]
Esophageal cancer	2B70	Phase 1/2	[2]
Gastric adenocarcinoma	2B72	Phase 1/2	[1]
Malignant glioma	2A00.0	Phase 1/2	[1]

• Cross-matching ID: TTD Drug ID: DMTQIB2

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Mucin-1 (MUC1)	TTBHFYQ	MUC1_HUMAN	CAR-T-Cell-Therapy	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Mucin-1 (MUC1)	DTT	MUC1	3.485	8.525	9.106	5.714
Mucin-1 (MUC1)	DTT	MUC1	3.485	8.525	9.106	5.714

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Colorectal cancer
• ICD Disease Classification: 2B91.Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Mucin-1 (MUC1)	DTT	MUC1	4.59E-01	-0.07	-0.41

References

• [1] ClinicalTrials.gov (NCT02617134) CAR-T Cell Immunotherapy in MUC1 Positive Solid Tumor
• [2] ClinicalTrials.gov (NCT03706326) CAR T and PD-1 Knockout Engineered T Cells for Esophageal Cancer