Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMTV4L7)

Drug Name

CHS-828 Drug Info

Synonyms

Cancer therapeutics, LEO Pharma; GMX-1778

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nicotinamide phosphoribosyltransferase (NAMPT)	TTD1WIG	NAMPT_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Solid tumour/cancer

ICD Disease Classification

2A00-2F9Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Nicotinamide phosphoribosyltransferase (NAMPT)	DTT	NAMPT	3.06E-08	-0.63	-0.59

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Anticancer agent CHS-828 inhibits cellular synthesis of NAD. Biochem Biophys Res Commun. 2008 Mar 21;367(4):799-804.