Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMTW9GM)

Drug Name
GW-2580 Drug Info
Synonyms GW2580; cFMS receptor tyrosine kinase inhibitor; GW632580X
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
11617559
CAS Number
CAS 870483-87-7
TTD Drug ID
DMTW9GM

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
CSF1R messenger RNA (CSF1R mRNA) TTVW6QL CSF1R_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
CSF1R messenger RNA (CSF1R mRNA) DTT CSF1R 7.727 7.423 6.924 7.156
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
CSF1R messenger RNA (CSF1R mRNA) DTT CSF1R 1.99E-05 0.39 0.56
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. Proc Natl Acad Sci U S A. 2005 Nov 1;102(44):16078-83.