Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMUE64H)

Drug Name
ISIS 107676 Drug Info
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
TTD Drug ID
DMUE64H

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Caspase 8 messenger RNA (CASP8 mRNA) TT6SZNG CASP8_HUMAN Not Available [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Caspase 8 messenger RNA (CASP8 mRNA) DTT CASP8 5.477 5.033 5.668 5.261
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Caspase 8 messenger RNA (CASP8 mRNA) DTT CASP8 8.78E-06 1.43 4.51
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 US patent application no. 6,258,600, Antisense modulation of caspase 8 expression.