Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMUGO9M)

Drug Name

Ac-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2 Drug Info

Synonyms

CHEMBL274874; Ac-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2; Acetyl-GRP(20-27); BDBM50012306; ZINC169366208

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Gastrin-releasing peptide receptor (GRPR)	TTC1MVT	GRPR_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Gastrin-releasing peptide receptor (GRPR)	DTT	GRPR	6.837	6.612	6.835	6.559

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Gastrin-releasing peptide receptor (GRPR)	DTT	GRPR	6.26E-01	-0.29	-0.6

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Gastrin releasing peptide antagonists with improved potency and stability. J Med Chem. 1991 Jul;34(7):2102-7.