General Information of Drug (ID: DMULTAI)

Drug Name
Imidazo[1,2-b]pyridazine derivative 1 Drug Info
Synonyms PMID28270010-Compound-Figure22-1
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Patented [1]
Cross-matching ID
PubChem CID
72695720
TTD Drug ID
DMULTAI

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Proto-oncogene c-Ros (ROS1) TTSZ6Y3 ROS1_HUMAN Inhibitor [1]
Tropomyosin-related kinase A (TrkA) TTTDVOJ NTRK1_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Tropomyosin-related kinase A (TrkA) DTT NTRK1 0.848 1.138 2.293 2.722
Proto-oncogene c-Ros (ROS1) DTT ROS1 5.511 4.406 4.973 4.823
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Solid tumour/cancer
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Tropomyosin-related kinase A (TrkA) DTT NTRK1 8.72E-01 -0.04 -0.22
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Tropomyosin receptor kinase inhibitors: an updated patent review for 2010-2016 - Part I.Expert Opin Ther Pat. 2017 Jun;27(6):733-751.