Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMUMCB9)

Drug Name

Amelubant Drug Info

Synonyms

Amelubant [INN]; BIIL 283 BS; BIIL 284; Ethyl ((4-((3-((4-(1-(4-hydroxyphenyl)-1-methylethyl)phenoxy)methyl)benzyl)oxy)phenyl)(imino)methyl)carbamate; Carbamic acid, ((4-((3-((4-(1-(4-hydroxyphenyl)-1-methylethyl)phenoxy)methyl)phenyl)methoxy)phenyl)iminomethyl)-, ethyl ester

Indication

Disease Entry	ICD 11	Status	REF
Pulmonary disease	1B10-1F85	Phase 2	[1]
Cystic fibrosis	CA25	Discontinued in Phase 2	[2]

Cross-matching ID

PubChem CID: 135564996
CAS Number: CAS 346735-24-8
TTD Drug ID: DMUMCB9

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Leukotriene B4 receptor 1 (LTB4R)	TTN53ZF	LT4R1_HUMAN	Antagonist	[3]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Leukotriene B4 receptor 1 (LTB4R)	DTT	LTB4R	5.154	4.45	5.062	5.057

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Pulmonary disease

ICD Disease Classification

1B10-1F85

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Leukotriene B4 receptor 1 (LTB4R)	DTT	LTB4R	3.40E-01	0.21	0.53

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	ClinicalTrials.gov (NCT02249338) Effect of BIIL 284 BS on Patients With Chronic Obstructive Pulmonary Disease (COPD) in Boehringer Ingelheim.
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8463).
3	Leukotriene receptor antagonists in children with cystic fibrosis lung disease : anti-inflammatory and clinical effects. Paediatr Drugs. 2005;7(6):353-63.