General Information of Drug (ID: DMUOWNE)

Drug Name
2-(3-Isopropyl-phenyl)-propionic acid Drug Info
Synonyms
Benzeneacetic acid, alpha-methyl-3-(1-methylethyl)-; CHEMBL191103; SCHEMBL1345333; DHFSUPPYOBITGY-UHFFFAOYSA-N; 2-(3-isopropylphenyl)propanoic acid; AKOS022699991; 2-[(3'-isopropyl)phenyl]propionic acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
10307922
TTD Drug ID
DMUOWNE

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
C-X-C chemokine receptor type 1 (CXCR1) TTMWT8Z CXCR1_HUMAN Inhibitor [1]
C-X-C chemokine receptor type 2 (CXCR2) TT30C9G CXCR2_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
C-X-C chemokine receptor type 1 (CXCR1) DTT CXCR1 4.912 3.858 3.897 3.7
C-X-C chemokine receptor type 2 (CXCR2) DTT CXCR2 2.722 1.202 1.202 0.848
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
C-X-C chemokine receptor type 1 (CXCR1) DTT CXCR1 1.29E-01 0.12 0.32
C-X-C chemokine receptor type 1 (CXCR1) DTT CXCR1 1.66E-01 0.07 0.2
C-X-C chemokine receptor type 2 (CXCR2) DTT CXCR2 8.82E-01 -0.23 -0.21
C-X-C chemokine receptor type 2 (CXCR2) DTT CXCR2 1.34E-01 0.21 0.19
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31.