Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMURWPH)

Drug Name
ISIS 104838 Drug Info
Indication
Disease Entry ICD 11 Status REF
Crohn disease DD70 Discontinued in Phase 2 [1]
Rheumatoid arthritis FA20 Discontinued in Phase 2 [1]
Therapeutic Class
Antisense
Cross-matching ID
PubChem CID
146028520
TTD Drug ID
DMURWPH

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
TNFA messenger RNA (TNF mRNA) TTC97NF TNFA_HUMAN Not Available [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
TNFA messenger RNA (TNF mRNA) DTT TNF 5.692 3.07 4.413 1.202
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Crohn disease
ICD Disease Classification DD70
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
TNFA messenger RNA (TNF mRNA) DTT TNF 1.24E-17 0.42 1.18
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013426)
2 Design and development of antisense drugs. Expert Opin. Drug Discov. 2008 3(10):1189-1207.