General Information of Drug (ID: DMUZ3OS)

Drug Name
1-adamantan-1-yl-3-(4-pentyloxycylclohexyl)urea Drug Info
Synonyms CHEMBL439577; CHEMBL2031926; 1-(1-adamantyl)-3-(4-pentoxycyclohexyl)urea; 1-adamantan-1-yl-3-(4-pentyloxycylclohexyl)urea; SCHEMBL3178050; BDBM50383478
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
11417158
TTD Drug ID
DMUZ3OS

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Soluble epoxide hydrolase (EPHX2) TT7WVHI HYES_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Soluble epoxide hydrolase (EPHX2) DTT EPHX2 8.353 7.227 6.421 8.192
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Soluble epoxide hydrolase (EPHX2) DTT EPHX2 8.78E-01 -0.1 -0.27
Soluble epoxide hydrolase (EPHX2) DTT EPHX2 4.40E-02 -0.18 -0.42
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 1,3-disubstituted ureas functionalized with ether groups are potent inhibitors of the soluble epoxide hydrolase with improved pharmacokinetic prope... J Med Chem. 2007 Oct 18;50(21):5217-26.