Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMV6RMB)

Drug Name
EPCAM-targeted CAR-T cells Drug Info
Indication
Disease Entry ICD 11 Status REF
Gastric adenocarcinoma 2B72 Clinical trial [1]
Liver cancer 2C12 Clinical trial [2]
Cross-matching ID
TTD Drug ID
DMV6RMB

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Tumor-associated calcium signal transducer 1 (EPCAM) TTZ8WH4 EPCAM_HUMAN CAR-T-Cell-Therapy [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Tumor-associated calcium signal transducer 1 (EPCAM) DTT EPCAM 4.307 10.904 9.628 10.804
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Gastric adenocarcinoma
ICD Disease Classification 2B72
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Tumor-associated calcium signal transducer 1 (EPCAM) DTT EPCAM 5.99E-02 -0.11 -1.11
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT02725125) Study Evaluating the Efficacy and Safety With CAR-T for Stomach Cancer
2 ClinicalTrials.gov (NCT02729493) Study Evaluating the Efficacy and Safety With CAR-T for Liver Cancer