Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMW1NKO)

Drug Name

X-82 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Age-related macular degeneration	9B75.0	Phase 2	[1]
Macular degeneration	9B78.3	Phase 1	[2]
Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Platelet-derived growth factor receptor (PDGFR)	TTI2WET	NOUNIPROTAC	Modulator	[3]
Vascular endothelial growth factor receptor (VEGFR)	TTVJ1D8	NOUNIPROTAC	Inhibitor	[4]
Vascular endothelial growth factor receptor 1 (FLT-1)	TT2Q6G1	VGFR1_HUMAN	Modulator	[3]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Vascular endothelial growth factor receptor 1 (FLT-1)	DTT	FLT1	4.802	4.95	4.597	3.17

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Age-related macular degeneration

ICD Disease Classification

9B75.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Vascular endothelial growth factor receptor 1 (FLT-1)	DTT	FLT1	4.94E-03	0.74	1.24

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	ClinicalTrials.gov (NCT02348359) X-82 to Treat Age-related Macular Degeneration. U.S. National Institutes of Health.
2	Clinical pipeline report, company report or official report of Tyrogenex.
3	National Cancer Institute Drug Dictionary (drug id 695817).
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)