Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMW2K1L)

Drug Name

LAS-31180 Drug Info

Synonyms

LAS-31180; LAS 31180; 137338-43-3; AC1Q6VQ1; AC1L50OY; ZINC8845; SCHEMBL7287896; DTXSID70160140; n-(1-methyl-4-oxo-1,4-dihydroquinolin-3-yl)methanesulfonamide; CS-6714; HY-101811

Indication

Disease Entry	ICD 11	Status	REF
Heart failure	BD10-BD13	Terminated	[1]

Cross-matching ID

PubChem CID: 195841
CAS Number: CAS 137338-43-3
TTD Drug ID: DMW2K1L

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Phosphodiesterase 3A (PDE3A)	TT06AWU	PDE3A_HUMAN	Modulator	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Phosphodiesterase 3A (PDE3A)	DTT	PDE3A	4.717	6.087	5.051	5.051

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Heart failure

ICD Disease Classification

BD10-BD13

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Phosphodiesterase 3A (PDE3A)	DTT	PDE3A	3.33E-01	1.35E-02	0.14

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Pharmacological profile of LAS 31180, a new inotropic/vasodilator quinolone derivative. Arzneimittelforschung. 2000 Nov;50(11):980-6.