Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMW9GT7)

Drug Name

DwLIP-GCGRrx Drug Info

Synonyms

UNII-T450D0Q71D; 1-Nitro-9-(3-dimethylaminopropylamino)-acridine dihydrochloride; 6514-85-8; Nitracrine HCl; ACRIDINE, 9-((3-(DIMETHYLAMINO)PROPYL)AMINO)-1-NITRO-, DIHYDROCHLORIDE; T450D0Q71D; 1,3-Propanediamine, N,N-dimethyl-N'-(1-nitro-9-acridinyl)-, dihydrochloride; CCRIS 9297; AC1L2LHF; SCHEMBL1652148; LS-14357; 1-NITRO-9-(DIMETHYLAMINOPROPYLAMINO)ACRIDINE DIHYDROCHLORIDE; dimethyl-[3-[(1-nitroacridin-9-yl)azaniumyl]propyl]azanium dichloride

Indication

Disease Entry	ICD 11	Status	REF
Diabetic complication	5A2Y	Investigative	[1]

Cross-matching ID

PubChem CID: 23015
CAS Number: CAS 6514-85-8
TTD Drug ID: DMW9GT7

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glucagon receptor (GCGR)	TT9O6WS	GLR_HUMAN	Binder	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Glucagon receptor (GCGR)	DTT	GCGR	4.695	1.926	1.322	3.797

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Diabetic complication

ICD Disease Classification

5A2Y

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Glucagon receptor (GCGR)	DTT	GCGR	7.24E-02	-0.52	-0.92

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2009).