Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMWA24P)

Drug Name
IPI-145 Drug Info
Synonyms Duvelisib; 1201438-56-3; INK-1197; UNII-610V23S0JI;
Indication
Disease Entry ICD 11 Status REF
Follicular lymphoma 2A80 Approved [1]
Small lymphocytic lymphoma 2A82.0 Approved [1]
Arthritis FA20 Phase 3 [2]
Cross-matching ID
PubChem CID
50905713
ChEBI ID
CHEBI:131169
CAS Number
CAS 1201438-56-3
TTD Drug ID
DMWA24P
VARIDT Drug ID
DR00276
ACDINA Drug ID
D01025

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PI3-kinase delta (PIK3CD) TTGBPJE PK3CD_HUMAN Modulator [3]
PI3-kinase gamma (PIK3CG) TTHBTOP PK3CG_HUMAN Modulator [3]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
PI3-kinase delta (PIK3CD) DTT PIK3CD 5.711 5.814 6.011 6.508
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Follicular lymphoma
ICD Disease Classification 2A80
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
PI3-kinase gamma (PIK3CG) DTT PIK3CG 1.98E-01 -0.05 -0.55
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 2018 FDA drug approvals.Nat Rev Drug Discov. 2019 Feb;18(2):85-89.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7795).
3 PI3K-delta and PI3K-gamma inhibition by IPI-145 abrogates immune responses and suppresses activity in autoimmune and inflammatory disease models. Chem Biol. 2013 Nov 21;20(11):1364-74.