Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMWIAUK)

Drug Name

ReN-1820 Drug Info

Synonyms

TrkAd5; HNGF, ReNeuron; Human nerve growth factor, ReNeuron; HNGF, Enact/University of Bristol; Human nerve growth factor, Enact/University of Bristol

Indication

Disease Entry	ICD 11	Status	REF
Cystitis	GC00	Terminated	[1]

Cross-matching ID

TTD Drug ID: DMWIAUK

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Low-affinity nerve growth factor receptor (NGFR)	TTEDJN4	TNR16_HUMAN	Inhibitor	[2]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Low-affinity nerve growth factor receptor (NGFR)	DTT	NGFR	5.524	1.848	2.807	2.678

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Cystitis

ICD Disease Classification

GC00

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Low-affinity nerve growth factor receptor (NGFR)	DTT	NGFR	5.08E-01	0.38	0.37

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800017720)
2	Phosphorylation of Extracellular Signal-Regulated Kinases (pERK1/2) in Bladder Afferent Pathways with Cyclophosphamide (CYP)-Induced Cystitis. Neuroscience. 2009 November 10; 163(4): 1353-1362.