Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMWIOCY)

Drug Name

HJP-272 Drug Info

Synonyms

Endothelin type A receptor antagonist (premature birth, inflammation); ETA antagonist (premature birth, lung inflammation), St Johns University; Endothelin type A receptor antagonist (premature birth, inflammation), St Johns University

Indication

Disease Entry	ICD 11	Status	REF
Premature labour	JB00	Investigative	[1]

Cross-matching ID

PubChem CID: 24997097
TTD Drug ID: DMWIOCY

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Endothelin A receptor (EDNRA)	TTKRD0G	EDNRA_HUMAN	Antagonist	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Endothelin A receptor (EDNRA)	DTT	EDNRA	3.776	4.505	5.121	3.536

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Premature labour

ICD Disease Classification

JB00

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Endothelin A receptor (EDNRA)	DTT	EDNRA	3.19E-05	-2.69	-1.71

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 219).