Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMWLPEB)

Drug Name
Naphthalene derivative 1 Drug Info
Synonyms PMID28454500-Compound-62
Cross-matching ID
PubChem CID
3294285
TTD Drug ID
DMWLPEB

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Keap1-Nrf2[dual DLG and ETGE] PPI (KEAP1-Nrf2 DLG and ETGE) TTGIZLN KEAP1_HUMAN-NF2L2_HUMAN Modulator [1]
Nuclear factor erythroid 2-related factor 2 (Nrf2) TTA6ZN2 NF2L2_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Nuclear factor erythroid 2-related factor 2 (Nrf2) DTT NFE2L2 8.964 8.362 9.046 8.808
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Nuclear factor erythroid 2-related factor 2 (Nrf2) DTT NFE2L2 4.75E-12 -0.28 -0.58
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Recent progress in the development of small molecule Nrf2 modulators: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Jul;27(7):763-785.