Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMWS7O9)

Drug Name

PMID23099093C17d Drug Info

Synonyms

GTPL8196; ZINC95559591; BDBM50401900

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Inhibitor of nuclear factor kappa-B kinase (IKK)	TTRPDBG	NOUNIPROTAC	Inhibitor	[1]
Microtubule affinity regulating kinase 3 (MARK3)	TT3DCYJ	MARK3_HUMAN	Inhibitor	[1]
NF-kappa-B-activating kinase (TBK1)	TTH5TC2	TBK1_HUMAN	Inhibitor	[1]
TGF-beta-activated kinase 1 (MAP3K7)	TTJQT60	M3K7_HUMAN	Inhibitor	[1]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Microtubule affinity regulating kinase 3 (MARK3)	DTT	MARK3	6.252	6.067	6.071	6.236

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Microtubule affinity regulating kinase 3 (MARK3)	DTT	MARK3	2.18E-06	0.13	0.48

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKepsilon kinases. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7169-73.