Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMX0VQN)

Drug Name

NSC-73410 Drug Info

Synonyms

NSC-73410; CHEMBL435920; 5138-23-8; NSC73410; Alizarine Saphirol SE; NCIOpen2_008926; SCHEMBL10706301; DTXSID50274577; ZINC3846907; 4,8-diamino-1,5-dihydroxy-9,10-dioxoanthracene-2-sulfonic acid; AC1L2850; BDBM50195862; 2-Anthracenesulfonic acid,8-diamino-9,10-dihydro-1,5-dihydroxy-9,10-dioxo-

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 16528
CAS Number: CAS 5138-23-8
TTD Drug ID: DMX0VQN

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Quinone reductase 1 (NQO1)	TT8XK6L	NQO1_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Quinone reductase 1 (NQO1)	DTT	NQO1	5.453	7.493	8.082	7.086

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Quinone reductase 1 (NQO1)	DTT	NQO1	2.05E-04	0.89	2.67

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	In silico identification and biochemical characterization of novel inhibitors of NQO1. Bioorg Med Chem Lett. 2006 Dec 15;16(24):6246-54.