Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMX2TZD)

Drug Name
DR-5/DR-4 cross reactive mabs Drug Info
Synonyms DR-5/DR-4 cross reactive mAbs (cancer); Death receptor-5/4 cross reactive mAbs (cancer), Crystal Bioscience; DR-5/DR-4 cross reactive mAbs (cancer), Crystal Bioscience
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Investigative [1]
Cross-matching ID
TTD Drug ID
DMX2TZD

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
TRAIL receptor 1 (TRAIL-R1) TT5WLRX TR10A_HUMAN Not Available [1]
TRAIL receptor 2 (TRAIL-R2) TTW20TU TR10B_HUMAN Not Available [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
TRAIL receptor 2 (TRAIL-R2) DTT TNFRSF10B 5.914 2.963 5.311 3.744
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Solid tumour/cancer
ICD Disease Classification 2A00-2F9Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
TRAIL receptor 2 (TRAIL-R2) DTT TNFRSF10B 1.03E-05 1.09 4.71
TRAIL receptor 1 (TRAIL-R1) DTT TNFRSF10A 4.44E-01 0.13 0.31
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1879).
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1880).