Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMX3FN4)

Drug Name

ISIS-APOCIII Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Atherosclerosis	BD40	Phase 1	[1]
Hyperlipemia	5C80	Phase 1	[1]
Inflammation	1A00-CA43.1	Phase 1	[1]
Metabolic syndrome x	5C50-5D2Z	Phase 1	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
ApoC-III messenger RNA (APOC3 mRNA)	TTXOZQ1	APOC3_HUMAN	Not Available	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
ApoC-III messenger RNA (APOC3 mRNA)	DTT	APOC3	12.577	4.597	2.293	10.581

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Atherosclerosis

ICD Disease Classification

BD40

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
ApoC-III messenger RNA (APOC3 mRNA)	DTT	APOC3	2.67E-01	0.1	0.59

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Clinical pipeline report, company report or official report of ISIS Pharmaceuticals (2011).