General Information of Drug (ID: DMX6ZYE)

Drug Name
Tarazepide Drug Info
Synonyms Tarazepide (INN)
Indication
Disease Entry ICD 11 Status REF
Gastrointestinal disease DE2Z Discontinued in Phase 2 [1]
Cross-matching ID
PubChem CID
10343641
CAS Number
CAS 141374-81-4
TTD Drug ID
DMX6ZYE

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Cholecystokinin receptor type A (CCKAR) TTCG0AL CCKAR_HUMAN Antagonist [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Cholecystokinin receptor type A (CCKAR) DTT CCKAR 3.907 4.133 2.858 3.892
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Gastrointestinal disease
ICD Disease Classification DE2Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Cholecystokinin receptor type A (CCKAR) DTT CCKAR 9.99E-01 -0.03 -0.2
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Cholecystokinin receptor-1 mediates the inhibitory effects of exogenous cholecystokinin octapeptide on cellular morphine dependence. BMC Neurosci. 2012 Jun 8;13:63.
2 Melatonin as modulator of pancreatic enzyme secretion and pancreatoprotector. J Physiol Pharmacol. 2007 Dec;58 Suppl 6:65-80.