Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMXBRCI)

Drug Name

NSC-180246 Drug Info

Synonyms

Poriol; NSC180246; 14348-16-4; NSC-180246; MLS000876957; SMR000440646; 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-methyl-2,3-dihydro-4H-chromen-4-one; 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methyl-chroman-4-one; 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methyl-2,3-dihydrochromen-4-one; 6-methylnaringenin; NSC 180246; AC1L6Z6F; CHEMBL484640; cid_301798; MEGxp0_000360; ACon1_000765; BDBM50571; MolPort-001-740-534; HMS2269A20; LMPK12140301; 4',5,7-Trihydroxy-6-methylflavanone; NCGC00169381-01; BRD-A47074844-001-01-5

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 301798
CAS Number: CAS 14348-16-4
TTD Drug ID: DMXBRCI

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	TTL53M6	MCL1_HUMAN	Inhibitor	[1]
Voltage-gated calcium channel alpha Cav2.2 (CACNA1B)	TT4FDG6	CAC1B_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	DTT	MCL1	7.695	6.404	5.954	6.82
Voltage-gated calcium channel alpha Cav2.2 (CACNA1B)	DTT	CACNA1B	4.087	2.433	1.632	3.392

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Voltage-gated calcium channel alpha Cav2.2 (CACNA1B)	DTT	CACNA1B	9.07E-01	7.11E-03	0.06

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6.