Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMXCD69)

• Drug Name: CEP1347 Drug Info
• Synonyms: AC1L31ZX; SCHEMBL1649555; ZINC103589452; DB05403

Indication

Disease Entry	ICD 11	Status	REF
Asthma	CA23	Phase 2/3	[1]

• Cross-matching ID:
  PubChem CID: 9917013
  CAS Number: CAS 156177-65-0
  TTD Drug ID: DMXCD69

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Mixed lineage kinase 1 (MAP3K9)	TTUNSIX	M3K9_HUMAN	Inhibitor	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Mixed lineage kinase 1 (MAP3K9)	DTT	MAP3K9	5.869	5.671	5.501	6.322

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• ICD Disease Classification: 12 Disease of the respiratory system
• Disease Class: ICD-11: CA23 Asthma
• The Studied Tissue: Nasal and bronchial airway
• The Studied Disease: Asthma [ICD-11:CA23]

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Mixed lineage kinase 1 (MAP3K9)	DTT	MAP3K9	9.49E-06	0.48	0.76

References

• [1] Targeting the JNK signaling pathway for stroke and Parkinson's diseases therapy. Curr Drug Targets CNS Neurol Disord. 2005 Feb;4(1):63-7.
• [2] Pharmacological inhibitors of MAPK pathways. Trends Pharmacol Sci. 2002 Jan;23(1):40-5.