Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMXFRW9)

Drug Name
6-(2-aminophenoxy)benzo[d]isothiazol-3-amine Drug Info
Synonyms CHEMBL458612; 6-(2-aminophenoxy)benzo[d]isothiazol-3-amine; SCHEMBL14241034; ZINC3818486; BDBM50274720; AKOS022180470; AJ-45722
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
44224215
TTD Drug ID
DMXFRW9

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Toll-like receptor 4 (TLR4) TTISGCA TLR4_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Toll-like receptor 4 (TLR4) DTT TLR4 5.853 5.555 6.158 5.82
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Toll-like receptor 4 (TLR4) DTT TLR4 5.26E-01 0.35 0.46
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Small molecule modulators of toll-like receptors. J Med Chem. 2008 Nov 13;51(21):6621-6.