Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMXM19W)

Drug Name

dequalinium Drug Info

Synonyms

dequalinium; Dequadin; 6707-58-0; UNII-E7QC7V26B8; Dequavagyn; Decamine; Labosept; Sorot; GNF-Pf-5483; E7QC7V26B8; CHEBI:41872; Polycidine; Dequavet; Dekadin; Rumilet; Dekamin; Sentril; Sanoral; Oralgol; Ivazil; Dequadin chloride; Dequalin chloride; C30H40N4; DEQ; 1,1'-decane-1,10-diylbis(4-amino-2-methylquinolinium); Solvidont; Quinolinium, 1,1'-(1,10-decanediyl)bis(4-amino-2-methyl-; 1-[10-(4-amino-2-methylquinolyl)decyl]-2-methyl-4-quinolylamine; CHEMBL121663

Indication

Disease Entry	ICD 11	Status	REF
Myelopathy	8B42	Clinical trial	[1]

Cross-matching ID

PubChem CID: 2993
ChEBI ID: CHEBI:41872
CAS Number: CAS 6707-58-0
TTD Drug ID: DMXM19W

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Calcium-activated potassium channel KCa2.1 (KCNN1)	TT9R6BE	KCNN1_HUMAN	Blocker (channel blocker)	[2]
Calcium-activated potassium channel KCa2.2 (KCNN2)	TT2T5M0	KCNN2_HUMAN	Blocker (channel blocker)	[3]
Calcium-activated potassium channel KCa2.3 (KCNN3)	TT9JH25	KCNN3_HUMAN	Blocker (channel blocker)	[1]
Cyclic nucleotide-gated channel alpha-1 (CNGA1)	TTHIQMC	CNGA1_HUMAN	Blocker (channel blocker)	[4]
Cyclic nucleotide-gated channel alpha-2 (CNGA2)	TT8SJGB	CNGA2_HUMAN	Blocker (channel blocker)	[5]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Calcium-activated potassium channel KCa2.2 (KCNN2)	DTT	KCNN2	5.34	4.233	1.485	2.536

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Myelopathy

ICD Disease Classification

8B42

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Calcium-activated potassium channel KCa2.2 (KCNN2)	DTT	KCNN2	5.17E-02	1.41E-02	0.15

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Pharmacological characterisation of the human small conductance calcium-activated potassium channel hSK3 reveals sensitivity to tricyclic antidepressants and antipsychotic phenothiazines. Neuropharmacology. 2001 May;40(6):772-83.
2	Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells. Br J Pharmacol. 2000 Mar;129(5):991-9.
3	Block of rat brain recombinant SK channels by tricyclic antidepressants and related compounds. Eur J Pharmacol. 2000 Jul 28;401(1):1-7.
4	Dequalinium: a novel, high-affinity blocker of CNGA1 channels. J Gen Physiol. 2003 Jan;121(1):37-47.
5	State-dependent block of CNG channels by dequalinium. J Gen Physiol. 2004 Mar;123(3):295-304.