Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMXMQAT)

Drug Name
RG-7273 Drug Info
Synonyms RG 7273; RG7273
Indication
Disease Entry ICD 11 Status REF
Lipid metabolism disorder 5C52.Z Discontinued in Phase 1 [1]
Cross-matching ID
TTD Drug ID
DMXMQAT

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
ATP-binding cassette transporter A1 (ABCA1) TTJW1GN ABCA1_HUMAN Inducer [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
ATP-binding cassette transporter A1 (ABCA1) DTT ABCA1 6.113 4.838 4.44 3.104
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Lipid metabolism disorder
ICD Disease Classification 5C52.Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
ATP-binding cassette transporter A1 (ABCA1) DTT ABCA1 4.88E-01 -0.1 -0.33
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031594)
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 756).