Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMXSFWK)

Drug Name
N1-benzyl-N3-hydroxy-2-isobutylmalonamide Drug Info
Synonyms CHEMBL220253; N1-benzyl-N3-hydroxy-2-isobutylmalonamide; BDBM50197494
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
16116576
TTD Drug ID
DMXSFWK

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Aminopeptidase N (ANPEP) TTPHMWB AMPN_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Aminopeptidase N (ANPEP) DTT ANPEP 8.744 7.809 8.914 11.49
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Aminopeptidase N (ANPEP) DTT ANPEP 8.84E-07 -0.3 -0.71
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 A library of novel hydroxamic acids targeting the metallo-protease family: design, parallel synthesis and screening. Bioorg Med Chem. 2007 Jan 1;15(1):63-76.