Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMXWG6Z)

Drug Name

A-798 Drug Info

Synonyms

A-429; A-655; A-665798; A-748; A-761; A-780748; MCHR-1 antagonists (obesity); Melanin concentrating hormone-1 receptor antagonists, Abbott; MCH-1 antagonists (obesity), Abbott; MCHR-1 antagonists (obesity), Abbott

Indication

Disease Entry	ICD 11	Status	REF
Obesity	5B81	Terminated	[1]

Cross-matching ID

TTD Drug ID: DMXWG6Z

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Melanin-concentrating hormone receptor 1 (MCHR1)	TTX4RTB	MCHR1_HUMAN	Antagonist	[2]

------------------------------------------------------------------------------------

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Melanin-concentrating hormone receptor 1 (MCHR1)	DTT	MCHR1	4.392	4.823	5.433	5.725

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Obesity

ICD Disease Classification

5B81

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Melanin-concentrating hormone receptor 1 (MCHR1)	DTT	MCHR1	6.98E-01	-0.01	-0.04

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021828)
2	Disruption of the melanin-concentrating hormone receptor 1 (MCH1R) affects thyroid function. Endocrinology. 2012 Dec;153(12):6145-54.