Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMY3T0L)

Drug Name

DS-1211 Drug Info

Synonyms

N-Acetyl-D-leucine; 19764-30-8; Ac-D-Leu-OH; D-leucine, N-acetyl-; N-Acetyl-R-leucine; (2R)-2-acetamido-4-methylpentanoic acid; Acetylleucine, D-; Acetylleucine, (R)-; (R)-2-acetamido-4-methylpentanoic acid; Leucine, N-acetyl-, D-; acetyl-d-leucine; 91WU82GA22; MFCD00066069; 2,N-Acetyl-D-leucine; D-acetylleucine; UNII-91WU82GA22; (R)-acetylleucine; N-acetyl-D-Leu; NCGC00094935-01; N-acetyl-(D)-leucine; SCHEMBL714003; CHEMBL174357; CHEBI:94479; DTXSID50361310; CHEBI:146296; WXNXCEHXYPACJF-SSDOTTSWSA-N; HY-Y1080; s4514; AKOS016842336; AKOS025117328; CCG-266380; CS-W020713; DS-1211; FD21901; NCGC00094935-02; AC-22376; A0713; AM20090137; A-1455; A20910; EN300-321381; Q-100200; BRD-K05831461-001-01-8; Z851793110

Indication

Disease Entry	ICD 11	Status	REF
Pseudoxanthoma elasticum	EC40	Phase 2	[1]

Cross-matching ID

PubChem CID: 1241420
TTD Drug ID: DMY3T0L

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Alkaline phosphatase tissue-nonspecific (ALPL)	TTMR5UV	PPBT_HUMAN	Inhibitor	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Alkaline phosphatase tissue-nonspecific (ALPL)	DTT	ALPL	6.35	4.07	5.7	3.609

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Pseudoxanthoma elasticum

ICD Disease Classification

EC40

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Alkaline phosphatase tissue-nonspecific (ALPL)	DTT	ALPL	4.67E-13	-0.15	-0.79

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	ClinicalTrials.gov (NCT05569252) A Phase 2, 12-Week, Randomized, Double-Blind, Placebo-Controlled Study of DS-1211b in Individuals With PseudoXanthoma Elasticum. U.S.National Institutes of Health.
2	In Vitro and In Vivo Pharmacological Profiles of DS-1211, a Novel Potent, Selective, and Orally Bioavailable Tissue-Nonspecific Alkaline Phosphatase Inhibitor. J Bone Miner Res. 2022 Oct;37(10):2033-2043.