Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMY5O1U)

• Drug Name: BENZOYLENUREA Drug Info
• Synonyms: Benzoyleneurea; 86-96-4; quinazoline-2,4(1H,3H)-dione; 2,4(1H,3H)-Quinazolinedione; 2,4-Dihydroxyquinazoline; Quinazolinedione; Benzouracil; Quinazoline-2,4-diol; Quinazoline-2,4-dione; 1H-Quinazoline-2,4-dione; Urea, benzoylene-; 1,2,3,4-Tetrahydroquinazoline-2,4-dione; 2-Keto-4-quinazolinone; 2,4-Dioxotetrahydroquinazoline; NSC 2108; (1H,3H)Quinazoline dione-2,4; (1H,3H)-Quinazoline-2,4-dione; EINECS 201-712-6; (1H,3H)Quinazoline dione-2,4 [French]; AI3-28016; CHEMBL421646; 1H,3H-quinazoline-2,4-dione; UNII-18K00A531C

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 64048
  CAS Number: CAS 86-96-4
  TTD Drug ID: DMY5O1U

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Phosphodiesterase 3A (PDE3A)	TT06AWU	PDE3A_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Phosphodiesterase 3A (PDE3A)	DTT	PDE3A	4.717	6.087	5.051	5.051

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Phosphodiesterase 3A (PDE3A)	DTT	PDE3A	3.33E-01	1.35E-02	0.14

References

• [1] CODES, a novel procedure for ligand-based virtual screening: PDE7 inhibitors as an application example. Eur J Med Chem. 2008 Jul;43(7):1349-59.