Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMYHR74)

• Drug Name: CP154,526 Drug Info
• Synonyms: CP-154526; 157286-86-7; CP 154,526; CHEMBL9946; CP154526; UNII-9A549FB00R; 9A549FB00R; CHEMBL475903; CP-154526-1; CP-154,526; N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-amine; N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)pyrrolo(2,3-d)pyrimidin-4-amine; PDSP1_001299; AC1NSJWW; CP154,526; butyl-(2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo(2,3-d)pyrimidin-4-yl)ethylamine; SCHEMBL5707848; GTPL3495; FHQYJZCJRZHINA-UHFFFAOYSA-N; ZINC1539133; BCP26372; BDBM50058163; BDBM50369802

Indication

Disease Entry	ICD 11	Status	REF
Depression	6A70-6A7Z	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5311055
  CAS Number: CAS 157286-86-7
  TTD Drug ID: DMYHR74

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Corticotropin-releasing factor receptor 1 (CRHR1)	TT7EFHR	CRFR1_HUMAN	Antagonist	[2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Corticotropin-releasing factor receptor 1 (CRHR1)	DTT	CRHR1	5.3	3.755	5.206	3.926

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Depression
• ICD Disease Classification: 6A70-6A7Z

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Corticotropin-releasing factor receptor 1 (CRHR1)	DTT	CRHR1	7.70E-01	-0.02	-0.1

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3495).
• [2] A review of drug options in age-related macular degeneration therapy and potential new agents. Expert Opin Pharmacother. 2006 Dec;7(17):2355-68.