Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMYK31O)

Drug Name
MDL-28170 Drug Info
Synonyms MDL-2170
Indication
Disease Entry ICD 11 Status REF
Alzheimer disease 8A20 Terminated [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [2]
Cross-matching ID
PubChem CID
72430
ChEBI ID
CHEBI:82818
CAS Number
CAS 88191-84-8
TTD Drug ID
DMYK31O
VARIDT Drug ID
DR00841

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Calpain-2 (CAPN2) TTG5QB7 CAN2_HUMAN Inhibitor [3]

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Alzheimer disease
ICD Disease Classification 8A20
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Calpain-2 (CAPN2) DTT CAPN2 5.15E-14 0.35 1.04
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003692)
2 A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals. April 17, 2020.
3 Synthesis of a small library of diketopiperazines as potential inhibitors of calpain. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3034-8.