Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMYLA29)

Drug Name

AD10-1025 Drug Info

Synonyms

AD10-369; AD10-371; AD10-797; AD10-798; Partial PPAR gamma agonist (oral, type 2 diabetes); Partial PPAR gamma agonist (oral, type 2 diabetes), Adamed SP; Phenyl propionic acid derivative 3 (oral, type 2 diabetes), Adamed SP; PPAR modulators (oral, hypercholesterolemia/NIDDM), Adamed

Indication

Disease Entry	ICD 11	Status	REF
Hypercholesterolaemia	5C80.0	Investigative	[1]

Cross-matching ID

TTD Drug ID: DMYLA29

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Insulin receptor (INSR)	TTCBFJO	INSR_HUMAN	Agonist	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Insulin receptor (INSR)	DTT	INSR	5.213	5.838	5.779	5.591

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Hypercholesterolaemia

ICD Disease Classification

5C80.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Insulin receptor (INSR)	DTT	INSR	1.03E-05	0.26	0.66

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1800).