Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMYOMSC)

Drug Name
Aderbasib Drug Info
Synonyms INCB-007839; INCB-7839; Sheddase inhibitors (anticancer), Incyte; ADAM inhibitors (oral, cancer), Incyte
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Phase 1/2 [1]
Cross-matching ID
PubChem CID
16070111
CAS Number
CAS 791828-58-5
TTD Drug ID
DMYOMSC

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Mammalian disintegrin-metalloprotease (ADAM10) TTOMWSY ADA10_HUMAN Modulator [2]
TNF alpha converting enzyme (ADAM17) TT6AZXG ADA17_HUMAN Modulator [3]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Mammalian disintegrin-metalloprotease (ADAM10) DTT ADAM10 5.86 6.053 6.109 5.874
TNF alpha converting enzyme (ADAM17) DTT ADAM17 4.995 5.443 5.278 5.225
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 02 Neoplasm
Disease Class ICD-11: 2C82 Prostate cancer
The Studied Tissue Breast tissue
The Studied Disease Breast cancer [ICD-11:2C82]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Mammalian disintegrin-metalloprotease (ADAM10) DTT ADAM10 9.12E-20 0.59 0.82
TNF alpha converting enzyme (ADAM17) DTT ADAM17 3.03E-08 0.15 0.45
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT02141451) INCB7839 With Rituximab After Autologous Hematopoietic Cell Transplantation for Diffuse Large B Cell Non-Hodgkin Lymphoma. U.S. National Institutes of Health.
2 Company report (Incyte)
3 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.