Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZ2D0G)

Drug Name

Anti-CD45 mabs Drug Info

Synonyms

AHCD45 therapy, Baylor College; YTH-24; YTH-24/54; YTH-25.4; YTH-54.12; Anti-CD45 mAbs (stem cell transplantation/cancer); Anti-CD45 mAbs (stem cell transplantation/cancer), Baylor College

Indication

Disease Entry	ICD 11	Status	REF
Lymphoma	2A80-2A86	Phase 1	[1]

Cross-matching ID

TTD Drug ID: DMZ2D0G

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Leukocyte common antigen (PTPRC)	TTUS45N	PTPRC_HUMAN	Not Available	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Leukocyte common antigen (PTPRC)	DTT	PTPRC	6.121	6.524	4.548	6.619

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Lymphoma

ICD Disease Classification

2A80-2A86

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Leukocyte common antigen (PTPRC)	DTT	PTPRC	5.86E-05	-0.26	-0.36

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	ClinicalTrials.gov (NCT00078546) EBV-Specific CTLs Following CD45 Antibody to Patients With Epstein-Barr Virus (EBV) + Nasopharyngeal Carcinoma (NPC). U.S. National Institutes of Health.
2	CD45 monoclonal antibody-mediated cytolysis of human NK and T lymphoma cells. Haematologica. 2006 Jul;91(7):886-94.