Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZ34P1)

• Drug Name: CGP-62464 Drug Info
• Synonyms: CGP-62464; CHEMBL169757; 5,7-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine; NSC606429; AC1Q4VCQ; 5,7-diphenyl-4-aminopyrrolo[2,3-d]pyrimidine; AC1L74EC; SCHEMBL5936176; ZINC1609260; BDBM50088900; NSC-606429; 121405-24-1; FT-0761196; 5,7-diphenylpyrrolo[2,3-d]pyrimidin-4-amine; 5,7-Diphenyl-7H-pyrrolo[2,3-d]pyrimidine-4-amine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 354471
  TTD Drug ID: DMZ34P1

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Proto-oncogene c-Src (SRC)	TT6PKBN	SRC_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Proto-oncogene c-Src (SRC)	DTT	SRC	2.907	3.35	3.498	4.75

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Proto-oncogene c-Src (SRC)	DTT	SRC	6.45E-01	-0.08	-0.58
Proto-oncogene c-Src (SRC)	DTT	SRC	2.08E-03	-0.52	-1.62

References

• [1] Substituted 5,7-diphenyl-pyrrolo[2,3d]pyrimidines: potent inhibitors of the tyrosine kinase c-Src. Bioorg Med Chem Lett. 2000 May 1;10(9):945-9.