Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZ5JNT)

Drug Name
PF-02367982 Drug Info
Synonyms CHEMBL1083754; BDBM50318934
Indication
Disease Entry ICD 11 Status REF
Endometriosis GA10 Investigative [1]
Cross-matching ID
PubChem CID
11964844
CAS Number
CAS 913344-84-0
TTD Drug ID
DMZ5JNT

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Progesterone receptor (PGR) TTUV8G9 PRGR_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Progesterone receptor (PGR) DTT PGR 1.848 1.888 1.263 0.138
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Endometriosis
ICD Disease Classification GA10
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Progesterone receptor (PGR) DTT PGR 3.26E-38 -3.79 -2.5
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Optimisation of a pyrazole series of progesterone antagonists; Part 1. Bioorg Med Chem Lett. 2010 Jun 1;20(11):3384-6.