General Information of Drug (ID: DMZ9MQ5)

Drug Name
3-methoxy-N',2-diphenylquinoline-4-carbohydrazide Drug Info
Synonyms CHEMBL218717; SCHEMBL3963611; WQHSKTAHWLQAGK-UHFFFAOYSA-N; BDBM50194593; 3-methyloxy-N',2-diphenyl-4-quinolinecarbohydrazide
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
44419758
TTD Drug ID
DMZ9MQ5

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Neuromedin-K receptor (TACR3) TTBPGLU NK3R_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Neuromedin-K receptor (TACR3) DTT TACR3 3.406 4.248 2.982 1.138
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Neuromedin-K receptor (TACR3) DTT TACR3 3.59E-01 0.04 0.12
Neuromedin-K receptor (TACR3) DTT TACR3 5.19E-01 -4.10E-03 -0.03
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists. Bioorg Med Chem Lett. 2006 Nov 15;16(22):5748-51.