Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZCSF1)

Drug Name
PMX-700 Drug Info
Synonyms SJ-005019; SJ-005059; DC-010-116; Temozolomide analogs (cancer), Pharminox
Indication
Disease Entry ICD 11 Status REF
Glioblastoma multiforme 2A00.0 Investigative [1]
Cross-matching ID
TTD Drug ID
DMZCSF1

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
DNA [cytosine-5]-methyltransferase 1 (DNMT1) TT6S2FE DNMT1_HUMAN Modulator [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
DNA [cytosine-5]-methyltransferase 1 (DNMT1) DTT DNMT1 6.508 6.687 6.296 6.565
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Glioblastoma multiforme
ICD Disease Classification 2A00.0
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
DNA [cytosine-5]-methyltransferase 1 (DNMT1) DTT DNMT1 0.00E+00 2.46 4.65
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2605).