Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMZEMG6)

Drug Name
Atiratecan Drug Info
Synonyms CH-0793011; CH-0793076; CH-4556300; TP-300
Indication
Disease Entry ICD 11 Status REF
Colorectal cancer 2B91.Z Discontinued in Phase 2 [1]
Cross-matching ID
PubChem CID
11592352
CAS Number
CAS 867063-97-6
TTD Drug ID
DMZEMG6

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
DNA topoisomerase I (TOP1) TTGTQHC TOP1_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Colorectal cancer
ICD Disease Classification 2B91.Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
DNA topoisomerase I (TOP1) DTT TOP1 6.65E-01 0.2 0.39
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024385)
2 Method development and validation of the simultaneous determination of a novel topoisomerase 1 inhibitor, the prodrug, and the active metabolite in human plasma using column-switching LC-MS/MS, and its application in a clinical trial. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Nov 15;879(30):3415-22.